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A meta-analysis of 15 randomized clinical trials showed that GCBE in amounts ranging from 90–6000 mg/day containing 30–1200 mg/day CGA for 1–12 weeks significantly reduced BW, BMI, and WC compared to the control group, but did not affect BF and waist-to-hip ratio . One study reported stomach irritation and dizziness following 800 mg GCBE (372 mg CGA)/day for 8 weeks , and the other reported nausea and headache following 200 mg CGA/day for 6 weeks . Animal studies suggest CGA is of low toxicity with an LD50 of 100 mg/kg (7 g for a 70 kg adult) [76,77]. No authoritative reports were identified specifically for GCBE; however, humans have a high metabolic capacity for CGA with no evidence of saturation of metabolic pathways for doses ≤2 g/day . The daily intake of CGA among coffee drinkers has been estimated to be 100–300 mg/day for medium drinkers and ≤600 mg/day for heavy drinkers . 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Keto can increase cortisol levels, which reduces thyroid hormone activation and increases TSH and it can be hard to get nutrients important for the thyroid gland on a keto diet. A keto diet could put people with hypothyroidism at an even greater risk for high cortisol levels, which can then increase their risk for diabetes and heart disease. So when you’re skipping carbs – as on a keto diet – your cortisol levels can go even higher (4). The keto diet usually calls for eating very low carb (50 grams or less), high fat, and moderate protein. Continue reading for my thoughts on why the ketogenic diet is bad news for hypothyroidism. While ingredients like apple cider vinegar may offer minor health benefits in the right context, they are not the miracle weight loss solution they’re claimed to be when packaged in a sugary gummy. The idea of taking a supplement to put your body into a fat-burning state of ketosis is certainly appealing. 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