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For example, a meta-analysis of metabolic syndrome clinical studies providing capsaicinoids ranging from 2–9 mg/day for 4–12 weeks combined food and supplement sources noted no serious adverse events and no events leading to withdrawal were reported in the studies . Related to supplements, EFSA evaluated phenylcapsaicin, a chemically synthesized analog of capsaicin for use in food supplements and foods for special medical purposes at a maximum of 2.5 mg/day in the general population above 11 years old . A search of the Mintel GNPD database indicated weight management supplements recommend Few authoritative and government reports related to capsaicinoids safety have been published. The role of the microbiota in healthy weight management is of high interest and in vitro studies have shown konjac fiber may beneficially alter the human gut microbiome ; however, human data on overweight/obese subjects are scarce. 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