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Currently, many researchers believe that SGLT2 inhibitors exert their cardioprotective effects by increasing ketone bodies. As the most advanced method for supplementing internal ketones, the ketone ester diet is superior to other methods in terms of safety and efficacy, with fewer disadvantages. The role of ketone bodies in the treatment of heart failure was further demonstrated by Takahara et al. (2021). In contrast, ketone esters have greater therapeutic significance for chronic heart failure. Ketone infusion is a method of directly supplementing ketones into the body. Different ketogenic methods and their cardioprotive effects. Table 1 summarizes the effects of different ketogenic methods on the cardiovascular system. Furthermore, as the duration of administration increases, the protective effects of ketones on the cardiovascular system also gradually increase. Fasting or long-term exercise can elevate ketone levels to over 1 mmol/L (Yurista et al., 2021b). Physiologically, the levels of circulating ketones in humans typically range from 0.05 to 0.1 mmol/L. Furthermore, studies have shown that ketones have an endothelium-dependent vasodilatory effect. In summary, these studies demonstrate that the gut microbiota plays an important mediating role between ketones and host physiology. However, the relationship between ketone metabolism and the pattern of DNA methylation and cardiac gene expression in heart failure is complex (Lother et al., 2021). This study revealed that H3K27me2 and H3K36me1, which are specifically upregulated histone modifications in ischemic heart failure, are sensitive to β-HB levels. Its ability to mitigate alcohol cravings can be particularly beneficial for individuals trying to maintain a healthier lifestyle and reduce their intake of empty calories from alcohol. This extract contains compounds that can help detoxify the liver, promoting better liver function and overall metabolic health. 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