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Consequently, despite the online availability of their data, we were unable to critically assess the appropriateness of the measures used in this paper. Some of the measures used in this paper were well-validated, including the Alternate Uses Task and Raven’s Progressive Matrices. Overall, studies in healthy subjects showed that CBD modulated brain activity and had opposite effects when compared to THC in resting state and during several cognitive paradigms (i.e., salience, emotional, memory, response inhibition, auditory/visual processing), following task-specific activation patterns. The current review provides a systematic literature overview of studies that investigated the acute effects of CBD on the human brain of healthy volunteers and individuals diagnosed with a psychiatric disorder. 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