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These gummies are now a part of my daily routine, and I wouldn’t go without them.” A small clinical trial with 50 participants with subclinical hypothyroidism found that ashwagandha root extract, at a dose of 300 mg twice daily for 8 weeks, lowered serum thyroid-stimulating hormone (TSH) and increased triiodothyronine (T3) and T4 levels compared with placebo . In one study, three adult men who took 500 mg/day of a standardized ashwagandha root and leaf extract for 8 weeks had small increases in blood thyroxine (T4) levels . Overall, the studies found that ashwagandha extract had a small but significant effect on improving sleep compared with placebo. In another trial conducted in India, 80 healthy men and women age 18 to 50 years, half of them with insomnia, were randomized to take an ashwagandha root extract (KSM-66) or placebo for 8 weeks . 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