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Aripiprazole has shown significant improvements in caregiver-rated and clinician-rated irritability, when compared with placebo.31 Similar to risperidone, side effects can be more common and severe than with other medications. However, the treatment group did report more sedation (17.9% vs. 11.1%), agitation (46.2% vs. 44.4%), and anorexia (15.4% vs. 11.1%) than those in the placebo group. The phase 2 clinical trial of balovaptan demonstrated no significant improvement in social responsiveness when compared with placebo after 12 weeks; however, measures of communication, socialization, and daily living skills showed improvement when compared with placebo, and this relationship strengthened with higher doses.24 Anagnostou et al.21 found some evidence for improvements in emotion recognition and a broad measure of quality of life in adults with ASD after receiving treatment with oxytocin. 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