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A 2023 study in 104 people with depression concluded that single-dose psilocybin-assisted psychotherapy rapidly reduced symptoms of depression within 8 days, with benefits lasting for 6 weeks. A 2021 study in 59 people with depression concluded that psilocybin-assisted psychotherapy did not reduce symptoms better than escitalopram, an antidepressant medicine, and psychotherapy. A 2020 analysis of 4 small studies in 117 people, most with life-threatening cancer, concluded that psilocybin combined with psychotherapy may be safe and effective for improving anxiety, depression, and existential distress, as well as quality of life. A 2022 national survey of substance use in students in grades 8, 10, and 12 reported that 4 percent of adolescents used psychedelics (referred to as “hallucinogens” in the survey) including psilocybin during the past 12 months. 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