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Short-chain fatty acids (SCFAs) such as butyrate, propionate, and acetate are predominant metabolites produced mainly through carbohydrate fermentation by specific species (36, 48). Factors influencing composition include age, sex, geography (35, 39, 40), stress (41), drug use (42, 43), and diet (44, 45). The ratio of fat types is specified in the MCT KD, and likewise, the ratios of carbohydrate types is specified in the LGIT. In another unique approach, this review then identifies potential consequent health outcomes specifically from these microbial impacts in order to make recommendations for practice and enable nutrition and healthcare professionals to make informed decisions when dealing with KD therapeutically. KD may alter the gut’s microbial composition that is fundamental to human health (7). For nutrition and healthcare professionals, the findings emphasize the importance of considering KDs microbial effects and resulting health implications at an individual level. 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