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The first clinical evidence that CBD was anxiolytic were studies demonstrating that CBD attenuated the anxiogenic effects of THC in healthy volunteers (Karniol et al. 1974; Zuardi et al. 1982). However, the UK National Institute for Health and Care Excellence (NICE) review of the literature in 2019 found that CBM was only 17% better than placebo (54% compared to 46%) at providing a 30% reduction in chronic pain (National Institute For Health And Care Excellence (NICE) Guidelines Updates Team. After over 2000 years of medicinal use by many cultures around the world, the most common indication for cannabis and cannabis-based medicine (CBM) use is still to relieve chronic pain (Boehnke et al. 2019; Ergisi et al. 2022). The main non-psychomimetic and non-addictive active compound of cannabis, CBD, may be useful for treating numerous neuropsychiatric disorders (De Gregorio et al. 2019), including chronic pain (Costa et al. 2007). 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