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Definitively, THC has been shown to directly bind CB1 and CB2 receptors, exerting psychoactive and other neurologically-mediated effects. The pathways by which exogenous cannabinoids such as ∆9-THC and CBD interact with the human endocannabinoid system (ECS) are complex and only partially understood. AEA and 2-AG are physiologic lipid-based retrograde neurotransmitters that interact with the ECS receptors and proteins in a similar manner to exogenous phytocannabinoids CBD and THC. Two endogenous ligands (endocannabinoids), were later discovered to bind to these cannabinoid receptors - N-arachidonoyl ethanolamide (AEA) and 2-arachidonoyl glycerol (2-AG) (Lader et al., 2009). As research continues to uncover the full potential of CBD in health management, products like Spectrum CBD Gummies are poised to play a significant role in the care and management of Type 2 Diabetes. 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