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Given the inseparable links of the cardiovascular and respiratory systems to support aerobic exercise performance, the effects of cannabis and THC consumption on respiratory function must be considered. Whether the myocardial effects of cannabis and THC impact exercise performance remains unclear, owing largely to uncertainty over whether the effects observed at rest persist during exercise—and if so, the extent of functional consequences. During exercise performance, cannabis induced increases in flow could be relevant given limited evidence that suggests that muscle blood flow may, to some degree, limit maximal exercise capacity . While the bona fide effects of cannabis on athletic performance are limited by an incomplete evidence-base with low ecological validity for athletes, the physiological actions of cannabis and THC offer important insight into perturbations of cardiorespiratory homeostasis through which cannabis may interact with performance. 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